The vampire brothers Damon and Stefan Salvatore, eternal adolescents, having been leading “normal” lives, hiding their bloodthirsty condition, for centuries, moving on before their non-aging is noticed. They are back in the Virginia town where they became vampires. Stefan is noble, denying himself blood to avoid killing, and tries to control his evil brother Damon, who promised to Stefan an eternity of misery. Stefan falls in love with schoolgirl Elena, who has an uncanny resemblance to the Salvatore brothers old love, Katherine; and whose best friend Bonnie is a witch.
Stefan searches tirelessly for Damon and Enzo months after their mysterious disappearance. No one can accept the loss of Damons humanity that Enzo hopes for too, Damon carelessly tries to prove everyone wrong. As Enzo continues to fight the control over him, Bonnie finds herself at the center of a deadly game and forced to make a heart wrenching decision involving two of the most important people in her life. At the Armory, Alaric researches a mysterious artifact that he hopes will help in their fight to get Damon and Enzo back. Finally, Damon’s downward spiral leads him to Tyler Lockwood who attempts to talk some sense into him before it’s too late.