When the pilot of a small aircraft has a heart attack and crashes his plane into the cockpit of a Boeing 747, several members of the flight crew are killed and the pilot is blinded. Miraculously, the 747 stays in the air on auto-pilot with flight attendant Nancy Prior at the controls. Ground controllers, including her boyfriend Alan Murdock, try to teach her the basics but they soon realize they will have to get a trained pilot into the cockpit. Their first attempt fails and Murdock realizes he will have to do it. Meanwhile, various passengers have their own problems including a young girl who is destined to a life saving operation.